WASHINGTON Researchers have found some of the
changes that a flu virus needs to become a deadly pandemic
strain, and said on Tuesday the H5N1 avian influenza virus has
so far made only a few of them.
They said their study can help scientists watch for the
mutations most likely to make H5N1 a global threat.
David Finkelstein of St. Jude Children's Research Hospital
in Memphis, Tennessee, and colleagues looked at H5N1 virus
samples from people who had been infected.
They found none were anywhere near as mutated as flu
viruses that caused the three most recent pandemics, notably
the 1918 "Spanish flu" that killed millions worldwide.
Writing in the Journal of Virology, Finkelstein's team said
they identified 32 clear-cut changes in influenza viruses that
differentiated a human flu from a bird flu.
Even when H5N1 viruses infected people, each one had made
one or two of these changes at the most, Finkelstein said.
"We think they need to get to 13 to be truly dangerous,"
Finkelstein said in a telephone interview. "We never saw
anything that approached the 13 that we saw in the Spanish
Health experts agree that the world is due for an influenza
pandemic. There were three in the last century.
The main suspect is the H5N1 avian flu, because it has
infected hundreds of millions of birds globally and has hopped
to people several times, killing 194 out of 321 people infected
Like most influenza viruses, it is mutating constantly. If
it makes just the right changes, it could pass easily from one
person to another, and that could mean millions of deaths. But
no one knows what mutations to look for.
BUILDING ON OTHER RESEARCH
Researchers have collected samples of flu viruses from all
over. And a team led by Dr. Jeffery Taubenberger of the U.S.
Armed Forces Institute of Pathology in Maryland resurrected the
1918 flu virus from preserved and buried samples.
Finkelstein's team compared the genetic sequences of these
viruses -- more than 9,800 avian viruses and 13,000 viruses
taken from human patients -- and compared them.
They found some markers -- DNA sequences that code for
amino acids, the basic building blocks of the proteins that
make up living organisms, including viruses.
"There are 32 very strong differences that we focused on
between the avian and the human flu," Finkelstein said.
"The pandemic virus from 1918, the Spanish flu, is halfway
between a bird virus and a human virus. What is reassuring is
the H5N1 appears be much more avian than that 1918 virus. So it
is still on the bird side of things, which is good."
They examined the sequences of viruses taken from seven
Indonesians killed in a cluster, who infected one another
through human to human transmission of the virus, as opposed to
catching H5N1 directly from a bird.
Among them, no virus had made more than two of the
identified changes needed to make a bird virus become a human
virus, Finkelstein said. That may explain why no one infected
anyone else during that cluster.