NEW YORK (Reuters Health) - A botanical ointment containing
sinecatechins, a green tea extract, is an effective and well
tolerated treatment for external genital and anal warts,
results of a controlled study confirm.
"Green tea catechins exert multiple biologic activities,
involving potent antiviral and antioxidant activity," Dr.
Silvio Tatti, now at the Hospital Clinicas, Universidad de
Buenos Aires, Argentina, and colleagues note in the journal
Obstetrics and Gynecology.
Given that genital and anal warts are caused by human
papillomavirus (HPV) and that effective, well tolerated
treatments are lacking, there has been interest in treatment
with sinecatechins ointments.
In their study, Tatti's team randomly assigned 502 adults
with 2 to 30 warts to either sinecatechins ointment (15% or
10%) or inactive ointment for up to 16 weeks or until the warts
In both sinecatechins groups, warts cleared completely in
roughly 57% of patients compared to just 34% of subjects in the
control group - a significant difference.
Clearance rates of at least 50% were seen in roughly
three-quarters of patients who applied sinecatechins ointment
compared with 51% of those who applied the inactive ointment.
Most side effects reported with sinecatechins ointment were
mild to moderate skin and application site reactions.
The results support the use of sinecatechins ointment for
external warts, Tatti and colleagues conclude. Sinecatechins
ointment, sold as Veregen, is approved for the topical
treatment of genital warts and perianal warts in health people
aged 18 and older.
SOURCE: Obstetrics and Gynecology, June 2008.