* Q4 EPS $0.18 vs est $0.01

* Says targets to be profitable in Q1

* Sees Q1 rev nearly $85 mln

* Sees 2010 rev $375 mln-$385 mln

* Shares rise 16 pct (Adds details; updates share movement)

Nov 5 (Reuters) - Laser-based tools maker Rofin-Sinar Technologies Inc (RSTI.O: Quote, Profile, Research) posted fourth-quarter results that handily beat estimates, helped by lower expenses, and said it targets to be profitable in the first quarter, sending its shares up more than 15 percent.

The company, which had posted a loss in the third-quarter, has seen the economic slowdown hurt its industrial clients.

"I would not give a red light to any of the industries we serve," Chief Executive Gunther Braun said on a conference call with analysts.

"But for the following industries, I see currently a sort of yellow light... tool industry, the automotive supplier and the jewelry business," he added.