* Q4 adj EPS $0.28 vs est $0.27

* Q4 rev $402.8 mln vs est $398.3 mln

* Sees Q1 2010 adj EPS $0.24-$0.26 vs est $0.30

* Sees Q1 rev $400 mln-$405 mln vs est $413.89 mln

* Shares down 8 pct

(Recasts; adds details from conference call)

By Anuradha Ramanathan

BANGALORE, Nov 9 (Reuters) - Hologic Inc (HOLX.O: Quote, Profile, Research) reported a fourth-quarter profit that beat market estimates by a cent helped by tightened costs, and raised its 2010 earnings forecast, but shares fell in after-market trade as some investors saw the outlook as conservative.

Shares of the company, which makes the ThinPrep test for cervical cancer and Selenia digital mammography systems, were trading widely between $14.05 and $15.35 in after-market trade.