UPDATE 1-Soccer-Iniesta inspires Barca to big win over Sevilla

(adds late results)

* Midfielder scores one and creates three

* Barca restore six-point lead over Real Madrid

* Valencia beat Betis to pressure Sevilla

* Malaga up to fifth with win at Osasuna

By Iain Rogers

MADRID, April 22 (Reuters) - Andres Iniesta scored a sublime goal and had a hand in three more to inspire Barcelona to a 4-0 humbling of third-placed Sevilla in the Primera Liga on Wednesday.

Champions Real Madrid had upped the pressure with a comeback win over Getafe which halved Barca's advantage to three points but Pep Guardiola's side responded in style to move on to 81 with six matches left.

Sevilla's third straight defeat left them on 57, two ahead of fourth-placed Valencia who won 2-1 at Real Betis thanks to a clinical double from striker David Villa.