Scientists identify key gene in type 1 diabetes

By Will Dunham

WASHINGTON (Reuters) - Scientists have pinpointed an important gene involved in increasing a child's risk for type 1 diabetes, a discovery they said may lead to a way to prevent the development of the disease.

The researchers at the Children's Hospital of Philadelphia and McGill University in Montreal said the new gene appears to be active almost exclusively in the body's immune cells.

Writing on Sunday in the journal Nature, the researchers said they scanned the genomes of about 6,000 people, half of whom had type 1 diabetes, also called juvenile diabetes.

They confirmed the role of four genes previously implicated in raising risk for the disease, and identified a fifth gene, called KIAA0350, that they believe plays the biggest part of any of them in type 1 diabetes susceptibility.

While it has a link to immune function, the researchers say they are not sure exactly what the link is.

"It's a gene of basically unknown function," Dr. Hakon Hakonarson, director of the Center for Applied Genomics at Children's Hospital of Philadelphia, who led the study, said in a telephone interview.

There are two versions of the gene, Hakonarson said. People with one version experience a 50 percent increase in risk for type 1 diabetes, while those with the other version are protected from the disease.

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