By Rodrigo Campos

NEW YORK, June 26 (Reuters) - Shares of non-U.S. companies traded on Wall Street ended mostly flat on Friday as a small decline in shares of Europe-based companies offset gains in those based in emerging markets.

New York-traded shares of French drug manufacturer Sanofi-Aventis (SNY.N: Quote, Profile, Research) tumbled for a second day on rumors that a damaging analysis on its blockbuster diabetes drug Lantus was soon to be published.

The company said new data on the drug's safety was inconclusive. For details, see [ID:nLQ702256]

The Bank of New York Mellon index of leading American Depositary Receipts (ADRs) dipped 0.05 percent while the U.S. benchmark S&P 500 index .SPX lost 0.15 percent.

The Bank of New York Mellon index of leading European ADRs shed 0.2 percent with Sanofi-Aventis ADRs falling 7.3 percent to $28.01, a day after a more than 5 percent decline in the stock.

The FTSEurofirst 300 index of top shares lost 0.13 percent, weighed down by drugmakers on Sanofi's news.

The Bank of New York Mellon index of leading Latin American ADRs rose 0.9 percent, as did benchmark indexes in Mexico .MXX and Chile .IGPA.

Leading Asian ADRs closed flat for the session, despite a 3.7 percent surge in Indian ADRs and a 1 percent increase in Chinese ADRs .

Indian shares rose on expectations the government will unveil market friendly reforms with its budget proposal, expected the first Monday of July.