Antibiotics, oral route cut "abortion pill" risks

By Gene Emery

BOSTON (Reuters) - Giving the "abortion pill" orally instead of vaginally and with antibiotics cut the risk of serious infection and death by 93 percent, researchers at Planned Parenthood reported on Wednesday.

The threat of infection is now down to 1 in 16,000 from one in 1,000, the researchers reported in the New England Journal of Medicine.

"Our goal was to make a safe procedure even safer," Planned Parenthood's Mary Fjerstad said in a telephone interview.

The "abortion pill" consists of giving mifepristone, also known as RU-486, to stop the pregnancy and a second drug, misoprostol, two days later to help the body expel the fetus.

At Planned Parenthood, where about 97,000 women receive a medical abortion each year, misoprostol was initially given vaginally because it is easily absorbed there.

Doctors began exploring alternative ways to give the treatment after four women from the U.S. and one in Canada died from a rare bacterial infection after receiving the abortion pill in 2005.

"When medical abortion was first introduced, there was little concern about the risk of infection, because there is no use of instruments in the cervix or uterus unless the procedure fails. However, it is clear that serious infections do occur," the researchers wrote.

In contrast, in Europe, where the treatment had been used far longer and the vaginal administration of misoprostol was less common, there were no deaths. In United Kingdom, pregnant women routinely received antibiotics.