* Trump replies to Russian threat to shoot down any missiles
* Trump to Russia: Don’t support “gas-killing animal” Assad
* Russia to Trump: Target “terrorists, not legal government”
* 43 dead from symptoms consistent with toxic chemicals -WHO
* Eurocontrol warns airlines of missile strike risk in Syria (adds Mattis, British opposition leader, Russian defence committee)
By Susan Heavey, Makini Brice and Tom Perry
WASHINGTON/BEIRUT, April 11 (Reuters) - U.S. President Donald Trump warned Russia on Wednesday of imminent military action in Syria over a suspected poison gas attack, declaring that missiles “will be coming” and lambasting Moscow for standing by Syrian President Bashar al-Assad.
Trump was reacting to a warning from Russia that any U.S. missiles fired at Syria over the deadly assault on a rebel enclave near Damascus would be shot down and the launch sites targeted.
His comments raised fears of direct conflict over Syria for the first time between the two world powers backing opposing sides in the seven-year-old civil war, which has aggravated instability across the Middle East.
“Russia vows to shoot down any and all missiles fired at Syria. Get ready Russia, because they will be coming, nice and new and ‘smart!’,” Trump wrote on Twitter.
“You shouldn’t be partners with a Gas Killing Animal who kills his people and enjoys it!” Trump tweeted, referring to Moscow’s alliance with Assad.
In response, Russia’s Foreign Ministry said: “Smart missiles should fly towards terrorists, not towards the lawful government”.
Foreign Ministry spokeswoman Maria Zakharova said any U.S. missile salvo could be an attempt to destroy evidence of the reported gas attack in the Syrian town of Douma, for which Damascus and Moscow have denied any responsibility.
U.S. Defense Secretary Jim Mattis, striking a cautious tone hours after Trump’s threat of missile strikes, said the United States was assessing intelligence about the suspected attack.
Asked if he had seen enough evidence to blame Assad, Mattis said: “We’re still working on this.”
He did not elaborate but added that the U.S. military stood ready to provide military options, if appropriate. It was unclear whether his remarks reflected any unease about Trump’s apparent move toward military action.
In Moscow, the head of a Russian parliamentary defence committee, Vladimir Shamanov, said Russia was in direct contact with the U.S. Joint Chiefs of Staff about the situation.
Dozens of people in Douma died and hundreds were injured in the attack, according to the World Health Organization (WHO).
After Trump’s tweet, the Syrian Observatory for Human Rights, a British-based war monitor, said pro-government forces were emptying main airports and military air bases.
The Russian military said it had observed movements of U.S. Navy forces in the Gulf. Any U.S. strike would probably involve the navy, given the risk to aircraft from Russian and Syrian air defences. A U.S. guided-missile destroyer, the USS Donald Cook, is in the Mediterranean.
The Syrian foreign ministry accused the United States, which has supported some rebel groups in Syria’s conflict, of using “fabrications and lies” as an excuse to hit its territory.
“We are not surprised by such a thoughtless escalation by a regime like the United States regime, which sponsored terrorism in Syria and still does,” the state news agency SANA cited an official source in the ministry as saying.
After the Douma attack, the insurgent group dug in there, Jaish al-Islam, finally agreed to withdraw. That clinched a huge victory for Assad, crushing a long rebellion in the eastern Ghouta region near the capital Damascus.
In London, British Prime Minister Theresa May said all the indications pointed to Syrian government responsibility for the Douma attack and such “a shocking and barbaric act” could not go unchallenged.
“We’re rapidly reaching an understanding of what happened on the ground,” she told reporters. “We’ll be working with our closest allies to consider how we can ensure that those responsible are held to account.”
The leader of the opposition Labour Party, Jeremy Corbyn, said however that the British parliament should be given a say on any military action.
Oil prices jumped to their highest level in more than three years on Wednesday after Trump’s missile warning, and U.S. stock index futures fell sharply due to alarm about a possible Russian-U.S. conflict over Syria.
White House officials did not immediately provide more detail about Trump’s remarks. The U.S. Defense Department said it did not comment on potential military actions.
The WHO said 43 people had died in Saturday’s attack on Douma from “symptoms consistent with exposure to highly toxic chemicals”, and more than 500 had been treated.
The WHO cautioned that it has no formal role in forensic inquiries into the use of chemical weapons. International inspectors are seeking clearance from Damascus to visit Douma under safe conditions to determine whether globally banned munitions were used, though they will not assign blame.
Moscow and Washington blocked attempts by each other at the United Nations Security Council on Tuesday to set up international investigations into chemical weapons attacks in Syria.
Moscow’s threat to down U.S. missiles came from its ambassador to Lebanon, Alexander Zasypkin, who said it was based on previous statements by President Vladimir Putin and the Russian armed forces chief of staff.
The Russian military said on March 13 that it would respond to any U.S. strike on Syria by targeting any missiles and launchers involved. Russia is Assad’s most powerful ally and its devastating air power has helped him wrest back large areas of territory from rebels since 2015.
Zasypkin also said a clash between Russia and the United States over Syria “should be ruled out and therefore we are ready to hold negotiations”.
With tensions growing, however, European air traffic control agency Eurocontrol warned airlines to exercise caution in the eastern Mediterranean due to the possible launch of air strikes into Syria over the next 72 hours.
Eurocontrol said air-to-ground and cruise missiles could be used within that period and there could be intermittent disruptions of radio navigation equipment.
Both Russia and Iran, Assad’s other main ally, have warned his enemies against military action in recent days, underlining their commitment to the Syrian government they have armed and supported through years of conflict.
Ali Akbar Velayati, the top adviser to Iranian Supreme Leader Ayatollah Ali Khamenei, said during a visit to Damascus on Tuesday that an Israeli attack on an air base in Syria earlier this week would “not remain without response”.
Israel held top-level security consultations on Wednesday amid concern it could be targeted by Syria or Iran if the United States strikes Syrian government forces.
Syria’s Russian-supplied air defences shot down an Israeli F-16 jet in February during a previous bombing run against what Israel described as Iranian-backed positions in Syria.
Last year, the United States carried out strikes from two Navy destroyers against a Syrian air base after another toxic gas attack on a rebel-controlled pocket.
Additional reporting by Dahlia Nehme in Beirut, Jeffrey Heller in Jerusalem, Michelle Nichols at the United Nations, Andrew Osborn and Maria Kiselyova in Moscow, Anthony Deutsch in Amsterdam, Steve Holland, Idrees Ali, Mark Hosenball, Phil Stewart and Patricia Zengerle in Washington, Jamie Freed in Singapore, Stephanie Nebehay in Geneva; Writing by Mark Heinrich and Angus MacSwan Editing by xxxx