LONDON, Jan 4 (Reuters) - Holders Manchester City began their assault on the FA Cup with a 4-1 victory over fourth-tier Port Vale but Manchester United and Wolverhampton Wanderers face an unwanted replay after drawing 0-0 at Molineux on Saturday.
Goals from Oleksandr Zinchenko, Sergio Aguero, Taylor Harwood-Bellis and Phil Foden ultimately made it a routine day for City, although Tom Pope had equalised for a Vale side sitting 74 places lower in the standings.
Manchester United, like City, made multiple changes to their starting lineup at Wolves in a tie that finally came alive in the second half after a lacklustre opening 45 minutes.
Marcus Rashford came off the bench to strike the bar for United and Matt Doherty had a goal ruled out for Wolves.
Leicester City, second in the Premier League, beat Wigan Athletic 2-0 and Bournemouth crushed Luton Town 4-0 in the other late kickoffs. (Reporting by Martyn Herman, editing by Ed Osmond)