November 20, 2007 / 2:36 PM / 12 years ago

Skin cells transformed without embryos

WASHINGTON (Reuters) - Researchers have transformed ordinary human skin cells into batches of cells that look and act like embryonic stem cells — but without using cloning technology and without making embryos.

An undated microscopic view of undifferentiated human embryonic stem cells. Two separate teams of researchers announced on Tuesday they had transformed ordinary skin cells into batches of cells that look and act like embryonic stem cells -- but without using cloning technology and without making embryos. REUTERS/University of Wisconsin/Handout

Their breakthroughs, reported on Tuesday, could make possible the long-sought goal of tailor-made medicine, but without the political, scientific and ethical roadblock of using human eggs or embryos.

“We can now envisage a time when a simple approach can be used to produce stem cells that are able to form any tissue from a small sample taken from any of us,” said Ian Wilmut of the University of Edinburgh, who helped clone the first mammal, Dolly the sheep, in 1997.

The White House immediately welcomed the development, given President George W. Bush’s long opposition to embryo research, even as scientists said the finding should not be the end of such research.

Two separate teams of researchers achieved the same goal, which doctors hope someday will lead to tailored medical treatments and a new approach called regenerative medicine, in which damaged organs can be re-programmed to repair themselves.

The researchers agree it will be years before the technique could be used to treat people. More immediately, they say it can be used to study diseases and to screen drugs.

James Thomson of the University of Wisconsin in Madison and colleagues reported their finding in the journal Science. Shinya Yamanaka of Kyoto University in Japan and colleagues reported theirs in the journal Cell.

The new cells are called induced pluripotent stem cells and look and act like embryonic stem cells — the master cells that give rise to every cell and tissue in the body.


Both teams used just four genes to transform ordinary skin cells called fibroblasts into induced pluripotent stem cells — iPS cells for short.

“These cells should be useful in understanding disease mechanisms, searching for effective and safe drugs, and treating patients with cell therapy,” Yamanaka said in a statement. His team got the cells to develop into heart cells, which then beat in unison.

“This work represents a tremendous scientific milestone — the biological equivalent of the Wright Brothers’ first airplane,” said Dr. Robert Lanza of Advanced Cell Technology, a company working in the same field.

“It’s not practical to use right now, but it might be in a few years. This is truly the Holy Grail — to be able to take a few cells from a patient — say a cheek swab or few skin cells — and turn them into stem cells in the laboratory.”

Yamanaka had first transformed mouse skin cells using four genes, and then tried his method on human cells. Thomson, whose team first discovered human embryonic stem cells in 1998, went straight to human cells using two of the same genes and two different genes.

Each method is likely to be patented separately.

Both teams said the new cells are not ready to use in people yet because they used a type of virus called a retrovirus to carry the new genes into the skin cells. It is not clear whether this virus might cause genetic mutations that could cause cancer or other side effects.

“Even though we have this nice new source of cells it doesn’t solve the downstream problem of getting them into the body and functioning,” Thomson said.

Wilmut was quoted by the Daily Telegraph this week as saying he was abandoning human cloning research to pursue the new approach.

But Thomson said he doubted many others in the limited field of human embryonic stem cell research would follow his lead.

“It is not the time to abandon embryonic stem cell research,” he said. “But I do believe that over time these cells will be used by more and more labs and human embryonic stem cells will be used by fewer and fewer labs.”

Editing by Will Dunham and Doina Chiacu

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