* Q4 GDP growth revised to 2.5 pct from 2.6 pct
* Booking Holdings, TJX gain after earnings
* Celgene falls after FDA rejects filing for MS drug
* Indexes: Dow off 0.7 pct, S&P down 0.4 pct, Nasdaq down 0.1 pct (Updates to late afternoon)
By Caroline Valetkevitch
NEW YORK, Feb 28 (Reuters) - U.S. stocks edged lower on Wednesday with a drop in energy shares, and the S&P 500 was on track for its biggest monthly fall since January 2016.
The S&P energy index fell 1.3 percent following sharply lower oil prices.
Retailer shares gained, however, following upbeat results.
Booking Holdings, formerly known as Priceline, rose 7.7 percent after reporting upbeat quarterly profit, helped by higher hotel bookings, while off-price apparel seller TJX jumped about 10 percent after posting upbeat same-store sales.
The S&P 500 and the Dow also were set to break a 10-month winning streak after a steep early-month selloff sparked by fears that higher inflation will prompt the Federal Reserve to hike interest rates more than investors are expecting.
Stocks have recovered some since then, but the trading has remained volatile.
“We’re seeing a little bit of reversal from some of the gains we saw last week. So we’re kind of bouncing around the 2,750 area,” said Paul Nolte, portfolio manager at Kingsview Asset Management in Chicago.
The Dow Jones Industrial Average fell 177.61 points, or 0.7 percent, to 25,232.42, the S&P 500 lost 9.95 points, or 0.36 percent, to 2,734.33 and the Nasdaq Composite dropped 7.84 points, or 0.11 percent, to 7,322.51.
About 76 percent of the S&P 500 companies that have reported so far have topped profit estimates, according to Thomson Reuters I/B/E/S. That is above the average 72 percent recorded in the past four quarters.
Celgene’s 8.1 percent drop was a drag on the healthcare sector after U.S. health regulators rejected the company’s application seeking approval of a multiple sclerosis drug.
Wall Street opened higher after the government revised lower its reading on economic activity in the fourth quarter to 2.5 percent. A regional gauge on U.S. Midwest factory activity fell more than forecast in February, while pending home sales unexpectedly declined in January.
The CBOE Volatility index, a measure of short-term stock market volatility, rose to 19.63.
Declining issues outnumbered advancing ones on the NYSE by a 1.78-to-1 ratio; on Nasdaq, a 1.87-to-1 ratio favored decliners.
The S&P 500 posted 15 new 52-week highs and 10 new lows; the Nasdaq Composite recorded 55 new highs and 62 new lows. (Additional reporting by Sruthi Shankar in Bengaluru; Editing by Anil D’Silva and Nick Zieminski)